E-Selectin/AAV2/2 Gene Therapy Alters Angiogenesis and Inflammatory Gene Profiles in Mouse Gangrene Model
For patients with chronic limb-threatening ischemia and limited revascularization options, alternate means for therapeutic angiogenesis and limb salvage are needed.E-selectin is a cell adhesion molecule that is critical for inflammation and neovascularization in areas of wound healing and ischemia.Here, we tested the efficacy of modifying ischemic